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Maternal Serum Prenatal Screen, Second Trimester

Source Blood
Mnemonic MATSC
Specimen Requirements

1 x 5 mL light green (mint) top PST tube. Gold top SST tube is also acceptable.

2.0 mL heparinized plasma or serum

Specimen Handling SUBMIT completed CLS Maternal Serum Prenatal Screen history form #CH3011.
Additional Information

Test includes:
- Estriol, Unconjugated (E3)
- Beta HCG, Quantitative - Blood
- AFP

Testing should be performed between 15 3/7 to 16 3/7 weeks gestation, not earlier.
Timing for ultrasound not crucial as calculation takes date into account. 

Testing Location Immunochemistry
Testing Frequency Weekdays
Alternate Name(s) Alpha-1-Fetoprotein; Biochemical Screen; Downs Syndrome Maternal Triple Screen; Triple Screen, Downs Syndrome
Reference Interval


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