Pentobarbital

Source	Blood
Mnemonic	PENTO
Specimen Requirements	2 x 5 mL red top tubes, NOT SST 2.0 mL serum Minimum Blood Volumes for Patients less than 45 kg (100 lb) Including Neonates and Pediatrics
Specimen Handling	Remove serum to properly labelled aliquot tube for transport and storage. If Toxicology staff not on site, deliver specimen to DSC Accession.
Additional Information	For additional information, see Half-life and time to Steady State. The correlation between dose and plasma concentration is influenced by pharmacogenetics.
Testing Location	Toxicology
Testing Frequency	As required
Alternate Name(s)	Nembutal
Reference Interval	Hypnotic (sedation): 4 - 22 µmol/L Therapeutic coma: 88 - 221 µmol/L (patients treated for elevated intracranial pressure) Concentration at which toxicity occurs varies and should be interpreted in light of clinical situation.

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