Thiocyanate

Source	Blood
Mnemonic	THIO
Specimen Requirements	2 x 5 mL gold top SST tubes preferred; 2 x 5 mL light green (mint) top PST tubes are also acceptable. 2.0 mL serum (or plasma) Minimum Blood Volume for Patients less than 45 kg (100 lb) Including Neonates and Pediatrics
Specimen Handling	DO NOT store serum (or plasma) on gel tube. Remove to properly labelled aliquot tube for transport and storage.
Additional Information	This test is indicated for measuring thiocyanate toxicity in patients on long-term nitroprusside therapy and with hepatic or renal dysfunction. It is not intended for monitoring occupational health surveillance due to cyanide exposure. Stat requests have restricted clinical indications and require review and approval by CLS Medical & Scientific Staff. Contact LIC at 770-3600 for Pathologist On Call information.
Testing Location	Toxicology
Testing Frequency	As required
Alternate Name(s)	Sodium Nitroprusside, Nipride
Reference Interval	Thiocyanate levels up to 0.5 mmol/L are seen with nitroprusside therapy. Thiocyanate levels greater than 1.4 mmol/L are reportedly toxic.

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