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Blood Component Administration

The administration of blood products is guided by the related procedures in the Regional
Nursing Policy and Procedure Manual. This includes information on administration sets,
needle size and infusion rates. Policy B-3 Blood Component/ Product Administration includes
information about the following:

• Pretransfusion testing
• Transfusion identification bands
• Issuing of blood components/ products
• Administration of blood components/ products
• Performing checks prior to transfusion
• Transfusion reactions

Intravenous Immune Globulin (IVIG) Administration Information

The following guidelines are for the infusion of IVIG preparations. These guidelines have
been prepared from the information provided by the manufacturer in the product insert.

• Most IVIG preparations are in a 10% concentration.
• The compatible solution for IVIG preparations (except Sandoglobulin) is D5W
  (5% dextrose in water) 
• Sandoglobulin 12% must not be mixed with other medical products in the
  same infusion line. 
  

Commercial Product Name (Concentration)	Product Name on Transfusion Tag	Product Insert Reference	Initial Infusion Rate	Maximum Infusion Rate	Comments
Manufacturer
Sandoglobulin 12%	SANDOGLOB 12%	February 15, 2007	0.3 mL/ kg/ hour for 60 minutes	1 mL/ kg/ hour	Not compatible with D5W. Flush line with normal saline.
CSL Behring
Gamunex/ IVIGnex 10%	GAMUNEX	08841856 (Rev July 2003)	0.01 to 0.02 mL/ kg body weight/ minute for 30 minutes	0.14 mL/ kg body weight/ minute	Only product suitable for rapid infusion rates. Suitable for diabetics.
Talecris Biotherapeutics
Gammagard S/D 10%	GAMMAGARD	Revised July 2000	0.5 mL/ kg/ hour (0.008 mL/ kg body weight/ minute for 30 minutes)	8 mL/ kg/ hour (0.103 mL/ kg body weight/ minute)	Antecubital veins are recommended site for infusion. Recommended for IgA deficiency with anti-IgA.
Baxter Corporation
Gammagard Liquid 10%	LIQ GAMMAGARD	April 12, 2006	0.5 mL/ kg/ hour (0.008 mL/ kg body weight/ minute for 30 minutes)	8 mL/ kg/ hour (0.103 mL/ kg body weight/ minute)	Antecubital veins are recommended site for infusion.
Baxter Corporation
CytoGam Cytomegalovirus Immune Globulin Intravenous (Human)	CMV IVIG	4-25-2000	15 mg IG/ kg/ hour	60 mg IG/ kg/ hour	Do not exceed 75 mL/ hour
CSL Behring

• If infusion at the initial rate is well tolerated, gradually increase the rate of infusion.
• If side effects occur, the rate may be reduced.
• The infusion may be interrupted until symptoms subside and the infusion restarted
  at the rate that is comfortable for the patient.

Calculating the rate per hour: Infusion rate (mL) x body weight (kg) x 60 minutes (hr)

Examples for a 70 kg patient:

Gammunex: 0.01 mL x 70 kg x 60 minutes = 42 mL/hour

Gammagard: 0.5 mL x 70 kg x 1 hour = 35 mL/ hour