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Molecular Diagnostics - Tissue Typing

The Tissue Typing Laboratory (TTL) of CLS is a state of the art laboratory that provides advanced molecular, serological and cellular testing for assessing donor-recipient compatibility for solid organ and bone marrow transplant programs; HLA disease association; and HLA-related pharmacogenetic testing.  TTL is located at CLS’ Diagnostic and Scientific Centre in the University Research Park. The Tissue Typing Laboratory is the only laboratory in Alberta accredited by the American Society for Histocompatibility and Immunogenetics (ASHI). TTL is a 24X7 STAT laboratory that provides services for the deceased donor solid organ transplant program.

The battery of molecular tests offered by TTL includes medium and high resolution molecular typing for HLA - class ! and !! genes for solid organ (kidney, pancreas and heart) and bone marrow transplant patients and donors;  HLA typing for aid in diagnosis of certain diseases, such as Celiac disease and Narcolepsy; and HLA B*1520 screening for Carbamazapine hypersensitivity.  In addition to these molecular tests, TTL also provides clinical services for HLA antibody screening and identification and T and B cell crossmatching for cadaver and living related donor solid organ transplantation and HLA antibody investigations for refractory patients and Bone Marrow Recipients receiving platelet transfusions.

The clinical tests provided by TTL are based on advanced molecular and cellular technologies including Sequence specific oligonucleotide probe (SSOP), Sequence specific primer (SSP) and automated DNA sequencing based molecular typing for HLA class ! and !! genes, Luminex based screening and identification of HLA antibodies and cytotoxity and Flow-cytometry based T and B cells crossmatching.

Our Clients include: Solid Organ Transplantation program of Southern Alberta, Bone Marrow Transplantation program of the entire province of Alberta, HIV clinic of Southern Alberta, Transfusion Medicine and various clinics in the Calgary region for the HLA disease association based diagnosis.

In addition to the clinical services, TTL is involved in strong research program that aims to identify molecular and functional immunogenetic biomarkers for the prediction of outcome and graft survival of solid organ and bone marrow transplantations. TTL is actively involved in development of new methods and tests and medical education through accredited and advanced residency training programs (Pathology, nephrology, Hematopathology and Clinical Hematology).

TTL policies, functioning and procedures strictly follows the best international standards dictated by major accreditation agencies like the American Society for Histocompatbility and Immunogenetics (ASHI) and certification boards like the American Board of Histocompatbility and Immunogenetics (ABHI).

Staffing

TTL is composed of a professional and expert team of scientists and technologists who work in tandem to make sure quality TTL services leading to best possible outcome and superior quality of life for our patients.  TTL is directed by Dr. Noureddine Berka, a PhD in Human Genetics from Howard University in Washington DC and fellow of ABHI.  Other members of the TTL team includes a histocompatibliity fellow, a Clinical Scientist, a Technologist III, a QA/QC officer and technical staff.  Seven members of the TTL technical staff are certified by ABHI as histocompatibility technologist or specialist.

Contact

Laboratory Leader:

Dr. Noureddine Berka, PhD, D (ABHI)
Tel:  (403) 770-3655
Fax:  (403) 770-3738

Laboratory:

Luz Stamm, BSc
Tel:  (403) 770-3593

Postal Address:

Tissue Typing Laboratory
Calgary Laboratory Services
9, 3535 Research Road NW
Calgary, AB  T2L 2K8

 

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Building Address: 3535 Research Road NW Calgary, Alberta T2L 2K8 Follow Us  Mailing Address: 9-3535 Research Road NW Calgary, Alberta T2L 2K8

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