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Amiodarone

Source Blood
Mnemonic AMIO
Specimen Requirements

2 x 4 mL red top tubes, NOT SST.

3.0 mL serum

Collect within 60 minutes of next dose.

Minimum Whole Blood Volumes for Micro-Collections using Microtainers 

Specimen Handling

PSC & RRL:
Centrifuge, pour off, and transport serum to DSC.

Extra-regional:
Centrifuge, pour off, and freeze serum prior to transport to DSC.

DSC:
Freeze specimens upon receipt in lab; ensure frozen specimens do not thaw.

Additional Information

Record time of last dose on requistion.

A minimum of at least 4 weeks is desirable between dosage changes for checking a level.

For additional information, see Half-life and Time to Steady State.

Testing Location Analytical Toxicology
Testing Frequency Once weekly
Alternate Name(s) Cordarone, Desethylamiodarone
Reference Interval

Amiodarone

1.5-3.9 mmol/L

Desethylamiodarone

1.3-3.5 mmol/L

Desirable amiodarone levels in patients treated for atrial fibrillation is between 1.1-2.2 µmol/L based on expert opinion.

Toxic Levels: The frequency of adverse effects is related to dosage and duration of therapy.

Click here for critical values