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C-1 Esterase Inhibitor, Total Protein and Function

Referred out for testing

Source Blood
Mnemonic C1ESTER and C1F
Specimen Requirements

Collections performed at acute care (RRL) sites and all PSCs.
Test cannot be collected by Mobile Collection Service (MCS).

2 x 3.5 mL gold top SST tube
2.0 mL serum

Keep tubes cold (immerse in ice water) before collecting and immediately after collection.

Note: Collection at PSC must occur at least 2 hours before the PSC closes to allow adequate time for clotting and processing.

Specimen Handling

PSC:
Allow to clot on ice, then centrifuge at 4ºC + 2ºC, and aliquot into 2 x 1 mL aliquot tubes. Freeze immediately and transport to DSC on ice in a separate bag with a photocopy of the requisition.

RRL and extra-regional: 
Allow to clot on ice, then centrifuge at 4ºC + 2ºC and aliquot into 2 x 1 mL aliquot tubes. Freeze immediately and transport to DSC on dry ice in a separate bag with a photocopy of the requisition.

DSC:
Place specimens in freezer upon receipt in lab; ensure frozen specimens do not thaw.

Additional Information Total protein and functional protein levels will be determined.
Testing Location University of Alberta
Testing Frequency
Alternate Name(s) Immuno-Complement Test; C-1 Inactivator; C1 Inhibitor and Function
Reference Interval