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Inducible Costimulatory Molecule

Source Blood
Mnemonic ICOS
Specimen Requirements

Pediatric: 1 x 4 mL dark green top sodium heparin tube

Adult: 2 x 4 mL dark green top sodium heparin tube

Minimum volume: 1.0 mL

Not accepted: EDTA, sodium citrate, ACD-A, lithium heparin

Specimen Handling

Specimens submitted to CLS from within Alberta: Mix well. DO NOT refrigerate, centrifuge or freeze. Deliver immediately to Flow Cytometry.

Specimens submitted to CLS from outside Alberta: DO NOT refrigerate, centrifuge or freeze samples. Ship at room temperature, using an overnight courier. Please follow Flow Cytometry Shipping and Handling instructions when sending to CLS.

Additional Information

Specimens submitted to CLS from within Alberta: Samples should be tested within 24 hours of collection.

Specimens submitted to CLS from outside Alberta: Use FC3200EP Flow Cytometry Out of Province Requisition.
For pricing and billing, refer to Flow Cytometry Billing and Pricing.

Biallelic inheritance of ICOS is a known cause of monogenic CVID. ICOS (CD278) expression on CD3+4+8- cells pre and post stimulation with PMA/Ionomycin is reported.

Testing Location Flow Cytometry
Testing Frequency Monday - Thursday
Alternate Name(s) ICOS
Reference Interval Provided on report.