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Leflunomide Metabolite

Source Blood
Mnemonic LEF
Specimen Requirements 1 x 3.5 mL red top tube, NOT SST

1 mL serum
Specimen Handling PSC & RRL:
Centrifuge, pour off, and transport serum to DSC. 

Extra-regional:
Centrifuge, pour off, and freeze serum prior to transport to DSC.

DSC:
Freeze specimens upon receipt in lab; ensure frozen specimens do not thaw. 
Additional Information Teriflunomide, the active metabolite of Leflunomide, is measured in this test.

This method has a detection limit of 0.5 ug/mL and is NOT indicated for verification of levels in women of childbearing potential who discontinue leflunomide and women receiving treatment who wish to become pregnant. The recommended procedure is that these patients undergo the cholestyramine drug elimination procedure which includes verification that plasma levels of teriflunomide are less than 0.02 ug/mL by two separate tests at least 14 days apart.
Testing Location Analytical Toxicology
Testing Frequency Every two weeks

 
Alternate Name(s)
Reference Interval