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Leucocyte Adhesion Deficiency

Source Blood
Mnemonic LAD
Specimen Requirements

Pediatric: 1 x 1.8 mL blue top sodium citrate

Adult: 1 x 8.5 mL yellow top ACD-A

Minimum volume: 0.5 mL

Also accepted: EDTA, sodium heparin

Specimen Handling Specimens submitted to CLS from within Alberta: Mix well. DO NOT centrifuge or freeze. Deliver immediately to Flow Cytometry.

Specimens submitted to CLS from outside Alberta: DO NOT centrifuge or freeze samples. Ship at room temperature or 4oC, using an overnight courier. Please follow Flow Cytometry Shipping and Handling instructions when sending to CLS.
Additional Information

Patient history required.

Specimens submitted to CLS from outside Alberta: Use FC3200EP Flow Cytometry Out of Province Requisition.
For pricing and billing, refer to Flow Cytometry Billing and Pricing.

Peripheral blood neutrophils are assessed for their expression of adhesion molecules CD18, CD11a, CD11b, and CD11c for investigation of Type I LAD, as well as CD15s for investigation of Type II LAD.

Testing Location Flow Cytometry
Testing Frequency Monday to Saturday
Alternate Name(s) LAD, Neutrophil Adhesion Markers CD18/11b/11a/11c
Reference Interval Provided on report.