Employee Login  |   Subscribe  |   Careers  |   Appointments
List All Test Names Beginning With:
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Macroprolactin

Source Blood
Mnemonic

CMISC AND PROL

Misc Chem Test field: Macroprolactin

Specimen Requirements

1 x 3 mL or 4.5 mL light green (mint) top PST tube. Gold top SST tube also acceptable.

0.5 mL plasma or serum

Specimen Handling CLS collection staff: transfer portion of plasma or serum to aliquot tube and label with CMISC label.
Additional Information

A Prolactin (PROL) must be ordered with each Macroprolactin order.

Macroprolactin is clinically indicated in patients with a prolactin concentration of 16 up to and including 115 ug/L for males and 26 up to and including 125 ug/L for females. Macroprolactin testing will be cancelled if the prolactin result is greater than these upper limit values or is within the reference interval.

Hyperprolactinemia may be caused by the presence of a high molecular mass complex containing prolactin and immunoglobulins called macroprolactin. In this situation, the patient is asymptomatic. Hyperprolactinemia attributable to macroprolactin can cause misdiagnosis and mismanagement of patients. Macroprolactinemia should be considered if, in the presence of elevated prolactin concentration, signs and symptoms of hyperprolactinemia are absent.

Prolactin is measured before and after polyethylene glycol precipitation of macroprolactin. Results are expressed as % recovery after this precipitation.
Testing Location Chemistry-DSC
Testing Frequency Daily
Alternate Name(s)
Reference Interval

< 40% recovery is indicative of macroprolactin
> 60% recovery is indicative of absence of macroprolactin
40 – 60% recovery indicates a grey zone