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Non-HDL Cholesterol, Calculated

Source Blood
Mnemonic LDL
Specimen Requirements See Cholesterol, Total - Blood for specimen requirements.
Specimen Handling

Additional Information Calculation:
Total Cholesterol - HDL Cholesterol
Testing Location Chemistry-DSC
Rural: BMSH
Testing Frequency Daily
Alternate Name(s)
Reference Interval

 < 18 years  No reference interval 
 18 - 150 years  0.0 - 4.2 mmol/L

For patients < 18 years:
Lipid Profile acceptable limits relative to dyslipidemia and atheroschlerosis risk:
    Total Cholesterol Acceptable < 4.40 mmol/L
    HDL-C Acceptable > 1.16 mmol/L
    LDL-C Acceptable < 2.84 mmol/L
    Triglycerides Acceptable < 0.85 mmol/L (0-9 years) OR < 1.02 mmol/L (10-17 years)
    Non-HDL-C Acceptable < 3.10 mmol/L

For patients 30 years of age or older:
The Framingham Risk Score (FRS), modified for family history, is recommended for risk assessment (2016 CCS Guideline, Can J Cardiol 2016.) FRS Calculation Resources can be found at www.myhealth.alberta.ca/Alberta/Pages/Heart -Disease-Risk-Calculator.aspx.

Low Risk (FRS < 10%)
Treatment advised if LDL-C > 5.0 mmol/L
Treatment target: > 50% reduction in LDL-C

Intermediate Risk (FRS 10 - 19%)
Treatment advised if:LDL-C > 3.5 mmol/L OR Non-HDL-C > 4.3 mmol/L OR ApoB > 1.2 g/L
Consider treatment for men > 50 years and women > 60 years with one additional CV risk factor
Treatment targets: LDL-C < 2.0 mmol/L or decrease by > 50% OR Non-HDL-C < 2.6 mmol/L OR ApoB < 0.8 g/L

High Risk (FRS > 19% or presence of high risk features)
Treatment advised in all patients
Treatment targets: LDL-C < 2.0 mmol/L or decrease by 50% OR Non-HDL-C < 2.6 mmol/L OR ApoB < 0.8 g/L