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Phosphorylated STAT3

Source Blood
Mnemonic PSTAT3
Specimen Requirements

Pediatric: 1 x 4 mL dark green top sodium heparin tube.

Adult: 2 x 4 mL dark green top sodium heparin tube.

Minimum volume: 1.0 mL

Not accepted: EDTA, ACD-A, sodium citrate, lithium heparin

Specimen Handling

Specimens submitted to CLS from within Alberta: Mix well. DO NOT centrifuge or freeze. Deliver immediately to Flow Cytometry.

Specimens submitted to CLS from outside Alberta: DO NOT centrifuge or freeze samples. Ship at room temperature or 4oC, using an overnight courier. Please follow Flow Cytometry Shipping and Handling instructions when sending to CLS.

Additional Information

Specimens submitted to CLS from within Alberta: Samples should be tested within 48 hours of collection.

Specimens submitted to CLS from outside Alberta: Use FC3200EP Flow Cytometry Out of Province Requisition.
For pricing and billing, refer to Flow Cytometry Billing and Pricing.

This functional assay measures phosphorylation of STAT3 in CD3+4+ T cells after incubation and signaling by IL-6. Antibody to pSTAT3 is employed using an intracellular staining technique. Flow cytometric assessment of pSTAT3 is useful for investigation of Hyper IgE Syndrome where autosomal dominant inheritance of a STAT3 mutation is suspected.

Testing Location Flow Cytometry
Testing Frequency Monday - Friday
Alternate Name(s) pSTAT3
Reference Interval Provided on report.