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Celiac Disease Screen

Source Blood
Mnemonic CELIAC or TTG
Specimen Requirements Collect 2 tubes:
1 x 3 mL light green (mint) top PST tube.  Gold top SST tube also acceptable.
and
1 x 3.5 mL gold top SST tube

If TTG IgG is ordered on requisition, refer to Tissue Transglutaminase Antibody IgG.

1 tube/aliquot is for IgA testing in Chemistry

Minimum Whole Blood Volumes for Micro-Collections using Microtainers
Specimen Handling
Additional Information

Test screen for gluten intolerance (Celiac Disease)

Initial test of Celiac Disease Screen includes TTG and IgA. Additional reflexive assays will be ordered as required and may include Anti-Endomysial Antibodies (AENDAB) and TTG IgG.

Note that initiating a gluten-free diet prior to referral or prior to screening will interfere with the diagnostic test for celiac disease.

Testing Location Immunochemistry
Testing Frequency Weekdays
Alternate Name(s) Anti-endomysial antibodies, EMA, Tissue Transglutaminase Antibody IgA, TTG IgA,
Reference Interval Anti-Endomysial Antibodies (AENDAB) - negative
Tissue Transglutaminase Antibody IgA  - < 20 kU/L
Tissue Transglutaminase Antibody IgG  - Interpretative ranges:
 < 1.0 - negative
 1.0 to 2.0 - weak positive
 > or = 2.0 - positive