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DOCK8 Protein Expression

Source Blood
Mnemonic DOCK8
Specimen Requirements

Pediatric: 1 x 4 mL dark green top sodium heparin tube

Adult: 1 x 4 mL dark green top sodium heparin tube

Minimum volume:0.5 mL

Not accepted: EDTA, sodium heparin

Specimen Handling

Specimens submitted to CLS from within Alberta: Mix well. DO NOT refrigerate, centrifuge or freeze. Deliver immediately to Flow Cytometry.

Specimens submitted to CLS from outside Alberta: DO NOT refrigerate, centrifuge or freeze samples. Ship at room temperature, using an overnight courier. Please follow Flow Cytometry Shipping and Handling instructions when sending to CLS.

Additional Information

Specimens submitted to CLS from outside Alberta: Use FC3200EP Flow Cytometry Out of Province Requisition.
For pricing and billing, refer to Flow Cytometry Billing and Pricing.

Flow cytometric quantitation of intracellular DOCK8 protein is used to screen for biallelic mutations of DOCK8 in Hyper IgE Syndrome investigations. In addition to lack of DOCK8 expression in a patient, carrier status can also be determined by flow cytometry. DOCK8 protein expression in lymphocyte subsets including T, B and NK is measured.

Testing Location Flow Cytometry
Testing Frequency Monday - Saturday
Alternate Name(s) DOCK8
Reference Interval Provided on report.