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Methylmalonic Acid - Blood

Source Blood
 
Mnemonic BGLBL

BGL Test Name Prompt: Methylmalonic
Specimen Requirements

1 x 4 mL dark green top sodium heparin tube, NOT PST.  Red top non-additive tube is also acceptable.

Minimum 0.5 mL plasma or serum.

Requires a minimum four-hour fast or just prior to next feed for newborns.

Specimen Handling Send a copy of the requisition with the specimen.

PSC:
Centrifuge, transfer plasma or serum to aliquot tube, write "Heparin"  or "Red Top" on the aliquot tube, and transport on ice to DSC.

RRL:
Centrifuge, transfer plasma or serum to aliquot tube, write "Heparin" or "Red Top" on the aliquot tube, and transport on ice to ACH.

Extra-regional:
Centrifuge, transfer plasma or serum to aliquot tube, write "Heparin" or "Red Top" on the aliquot tube, and freeze prior to transport to DSC.
     
DSC:
Freeze serum upon receipt in lab; ensure frozen specimens do not thaw.
Additional Information Plasma methylmalonic acid can aid in the diagnosis of functional B12 deficiency when the plasma B12 levels are in the low-normal range (150 to 400 pmol/L). This test should only be ordered when there is a high index of clinical suspicion of B12 deficiency.
 
Testing Location ACH Biochemical Genetics Lab
Testing Frequency Weekly
 
Alternate Name(s) Methylpropanedioic Acid - Blood; Isocuccinic Acid - Blood
 
Reference Interval Provided on test report.