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Methylmalonic Acid - Urine

Referred out for testing

Source Urine
 
Mnemonic BGLNON

BGL Non-Blood Test Name field: Methylmalonic
Specimen Requirements

Prefer 5-10 mL random urine, or 5-10 mL of 24-hour urine with no preservative is also acceptable.

Minimum: 1.0 mL urine.

Specimen Handling

Send a copy of the requisition with the specimen.

If specimen is transferred to secondary container, write "random urine" or "24-hour urine" as appropriate on label.

PSC:
Send on ice to DSC.

RRL:
Send on ice to ACH.

Extra-regional:
Freeze before transport to DSC.

DSC:
Freeze specimens upon receipt in lab; ensure frozen specimens do not thaw.

Additional Information

Urine methylmalonic acid can aid in differentiating between a true functional B12 deficiency and renal insufficiency, both of which can lead to a mild to moderate elevation of plasma methylmalonic acid.

This test should not be ordered in conjunction with urine organic acids, as this metabolite is also reported as part of that test, and this test will be reflexively performed on any urine sample with elevated levels detected. 

Testing Location ACH Biochemical Genetics Lab
Testing Frequency Weekly; must notify ACH Biochemical Genetics Lab for priority turn-around.
Alternate Name(s) Methylpropanedioic Acid - Urine; Isosuccinic Acid - Urine; MMA - Urine
Reference Interval Provided on test report.