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Sirolimus

Source Blood
Mnemonic SIRO
Specimen Requirements

1 x 4 mL lavender top EDTA tube
Whole blood

Minimum Whole Blood Volumes for Microcollections

Collect just prior to next dose.

Stat priority requests have restricted clinical indications and require review and approval by CLS Medical & Scientific Staff.   Contact LIC at 403-770-3600 for Pathologist On Call information.

Specimen Handling

Record date and time of last dose on requisition.

Must be received at DSC by 12:30 Monday to Friday and 11:00 Saturday, Sunday and holidays for same day analysis. If not received before designated time, sample will be processed the next day.

Additional Information

If Sirolimus, Tacrolimus, and Cyclosporin are ordered in any combination, they may be collected in one tube.

For additional information, see Half-life and Time to Steady State.

Testing Location Analytical Toxicology
Testing Frequency Daily
Alternate Name(s) Rapamycin, Rapamune
Reference Interval

Click here for critical values

Results interpreted by clinician.  Interpretation is dependent upon various factors such as transplant type, time post transplant, and concomitant immunosuppressive therapy.  Result determined by tandem mass spectrometry.